I would like a high-impact, minimalist design that works as both a paperback and ebook cover. But don't make it too generic. I want a gritty, scary, distressed look. The ebook cover has to be easy to read as a smaller icon. I like white, red and black for impact, but don't limit yourself to just that.
The book has many references to the color white. The three parts of the book are titled: White Mouse, White Bear, Whiteout. Much of the action of the story takes place in the winter in Yellowstone National Park. Doctor Mosquito is a genetically modified mosquito that can deliver medicine, vaccinations and gene therapies. In the story it is also used to create genetically-modified monster animals. One of the defining characteristics of the genetically-modified polar bear that terrorizes people throughout the book is that it can turn invisible. So, there are a lot of reference to white, invisibility, camouflage, and stealth.
But I would like to see your ideas. Cover images can include: snow, woods, polar bear, mosquito, DNA, syringe, blood, black helicopter, bear prints, wolves, wolf prints, bullet shells. See the "winter landscape" image I uploaded for mood. If you want your design to stand out, don't just put black text on white. I want to see other ideas too -- woods, snow, etc.