Restoring Muscle Strength Using Gene Therapy

The t-shirt will celebrate the partnership between Dyno Therapeutics and Sarepta on a project that aims to develop gene therapy to restore the ability to walk and muscle strength in patients with rare muscle disorders. A protein shell, in the shape of an icosahedron (see the icosahedron image attached for an example of this 3-dimensional shape), is used to deliver the gene to treat the condition. We want a creative way to incorporate the icosahedron shape as well as muscle into the design. Part of our process uses Artificial Intelligence, machine learning, big data, and thousands of data points, so feel free to incorporate these ideas. Here are 4 design concepts to consider: 1. One design concept incorporates sarcomere image attached (the balck and white PNG), this design could lead to more abstract/minimal line drawings (e.g. Polynesian art). 2. Another design concept could interweave the three different types of muscle. These cell types are distinct, so careful attention should be given to the anatomical differences between these tissues. (Please see the image of muscle types) 3. Another concept here could be to incorporate these immunofluorescence muscle expression patterns (the green images attached). The most common genetic disorder associated with muscle is Duchenne Muscular Dystrophy, in which patients have mutations in the gene that encodes dystrophin, a key structural protein. When we look at dystrophin expression in skeletal muscle, we can see expression patterns such as the green images attached. The first image (immunofluorescence microscopy) is a snapshot of dystrophin expression in healthy muscle and the second is the lack of dystrophin expression in a patient with Duchenne Muscular Dystrophy. The third image is the same patient treated with gene therapy, where the AAV capsid delivers the dystrophin gene. 4. The last concept is more informal, placing a pair of biceps (skeletal muscle) on the icosohedron of the AAV Capsid. Please see the picture attached of arms with the icosahedron shape.

- Refer to the shirt layout example photo for an example of the layout we would like - Use unaltered Dyno and Sarepta logos; monochrome for logos - Use 2 sides of the shirt - Back of T shirt displays the logos and the text: “Partnership Est. 2020” - Front has the main design and preferably no text - we have a preference for a white or light gray tshirt color, but could use a color provided in the color palette PDF

- only use the colors provided in the color palette PDF - do not alter the logos

Toda categoría de diseño tiene precios flexibles para todos los presupuestos. Camiseta comienza en $199.